毛壳素Chaetocin
Methyltransferase inhibitor
Chaetocin, an antitumor antibiotic, is a thiodioxopiperazine natural product produced by Chaetomium species. Specific inhibitor of the lysine-specific methyltransferase SU (VAR)3-9 both in vitro and in vivo. It displays potent antimyeloma activity in IL-6-dependent myeloma cell lines. Its antimyeloma activity appears to be due to induction of oxidative stress and consequent apoptosis.
PRODUCT PROPERTIES
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Source/Host:
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Isolated from Chaetomium sp-
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Solubility:
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Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml), dimethyl formamide or methanol. Poorly souble in water.
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Long Term Storage:
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-20°C
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Use/Stability:
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Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
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Hazard:
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HARMFUL.
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MW:
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696.9
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CAS:
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28097-03-2
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Formula:
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C30H28N6O6S4
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Purity:
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≥ 98% (TLC)
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Appearance:
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White to off-white solid.
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普华仕科技发展有限公司 --Puhuashi Technology Development Co., Ltd
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